Posted on November 11, 2008 by
Measurement of panic-like responses following intravenous infusion of sodium lactate in panic-prone rats.
Indiana University Medical Center, Indianapolis, Indiana, USA.
This unit describes a putative animal model for panic disorder. The basic premise is that pharmacological disruption of critical brain regions implicated in the circuitry of anxiety will lead to a condition similar to that of the human disorder. A clinically relevant test, the sodium lactate challenge, is utilized to assess parallels between the human condition and this rat model.
PMID: 18428590 [PubMed – indexed for MEDLINE]