Posted on October 15, 2012 by
Good news. Time to start a proper curcumin trial.
Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults
- Yen Ying Lim, MPsych,
- Kathryn A. Ellis, PhD,
- Robert H. Pietrzak, PhD, MPH,
- David Ames, MD,
- David Darby, MBBS, PhD, FRACP,
- Karra Harrington, BA,
- Ralph N. Martins, PhD,
- Colin L. Masters, MD,
- Christopher Rowe, MD,
- Greg Savage, PhD,
- Cassandra Szoeke, PhD,
- Victor L. Villemagne, MD,
- Paul Maruff, PhD and
- For the AIBL Research Group
+ Author Affiliations
From the Mental Health Research Institute (Y.Y.L., K.A.E., D.D., K.H., C.L.M., V.L.V., P.M.), Department of Psychiatry (Y.Y.L.), and Academic Unit for Psychiatry of Old Age, Department of Psychiatry (K.A.E., D.A.), The University of Melbourne, Parkville, Australia; National Ageing Research Institute (K.A.E., D.A., C.S.), Parkville, Australia; Department of Psychiatry (R.H.P.), Yale University School of Medicine, New Haven, CT; Florey Neuroscience Institutes (D.D.), The University of Melbourne, Carlton South, Australia; Centre of Excellence for Alzheimer’s Disease Research and Care, School of Exercise, Biomedical and Health Sciences (R.N.M.), Edith Cowan University, Perth, Australia; Department of Nuclear Medicine and Centre for PET (C.R., V.L.V.) and Department of Medicine (C.R.), Austin Health, The University of Melbourne, Heidelberg, Australia; Department of Psychology and ARC Centre of Excellence in Cognition and Its Disorders (G.S.), Macquarie University, Sydney, Australia; and CogState Ltd. (P.M.), Melbourne, Australia.
- Correspondence & reprintrequests to Dr: Lim: firstname.lastname@example.org
Objective: Although the APOE ?4 allele is associated with more rapid decline in memory in healthy older adults, the significance of elevated cerebral ?-amyloid (A?) load for longitudinal changes in cognition is unclear.
Methods: Healthy and cognitively normal older adults (n = 141; mean age 76 years) underwent PET neuroimaging for cerebral A?, APOE genotyping, and cognitive assessment as part of their baseline assessment in the Australian Imaging Biomarkers and Lifestyle study. Cognitive function was reassessed 18 months later.
Results: Linear mixed-model analyses adjusted for baseline cognitive function indicated that, relative to individuals with low cerebral A?, individuals with high cerebral A? showed significantly greater decline in working memory and verbal and visual episodic memory at 18 months. Compared with noncarriers, APOE ?4 carriers showed a greater decline in visual memory at the 18-month assessment. No interaction between APOE ?4 and cerebral A? load was observed for any measure of cognitive function.
Conclusions: In this prospective study of healthy older adults, high cerebral A? load was associated with greater decline in episodic and working memory over 18 months. The APOE ?4 genotype was also associated with a decline in visual memory, although the effect was less than that observed for cerebral A? load.
- Received February 22, 2012.
- Accepted May 29, 2012.
- Copyright ? 2012 by AAN Enterprises, Inc.