Posted on November 25, 2012 by
Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1878-82. Epub 2012 Jan 23.
Negative and competitive social interactions are related to heightened proinflammatory cytokine activity.
Chiang JJ, Eisenberger NI, Seeman TE, Taylor SE.
Department of Psychology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Research has consistently documented that social relationships influence physical health, a link that may implicate systemic inflammation. We examined whether daily social interactions predict levels of proinflammatory cytokines IL-6 and the soluble receptor for tumor necrosis factor-? (sTNF?RII) and their reactivity to a social stressor. One-hundred twenty-two healthy young adults completed daily diaries for 8 d that assessed positive, negative, and competitive social interactions. Participants then engaged in laboratory stress challenges, and IL-6 and sTNF?RII were collected at baseline and at 25- and 80-min poststressor, from oral mucosal transudate. Negative social interactions predicted elevated sTNF?RII at baseline, and IL-6 and sTNF?RII 25-min poststressor, as well as total output of sTNF?RII. Competitive social interactions predicted elevated baseline levels of IL-6 and sTNF?RII and total output of both cytokines. These findings suggest that daily social interactions that are negative and competitive are associated prospectively with heightened proinflammatory cytokine activity.
[PubMed – indexed for MEDLINE]
Free PMC Article