Vitamin D and multiple sclerosis: a critica… [Acta Neurol Belg. 2012] – PubMed – NCBI

Vitamin D and multiple sclerosis: a critica… [Acta Neurol Belg. 2012] – PubMed – NCBI.

Acta Neurol Belg. 2012 Dec;112(4):327-33. doi: 10.1007/s13760-012-0108-z. Epub 2012 Jul 6.

Vitamin D and multiple sclerosis: a critical review and recommendations on treatment.


Department of Neurology, University of California, San Francisco, USA.


Multiple sclerosis (MS) is an immune-mediated and degenerative disease of nervous system, which affects mostly young adults. Vitamin D deficiency is a well-known environmental risk factor for MS and is considerable in terms of immediate clinical implications. In addition to its classical action on regulation of bone homeostasis, vitamin D may have a potent impact on cytokine profiles and neuro-inflammation. Given the immunomodulatory effects of vitamin D and its high rate of deficiency in MS patients, prescribing vitamin D is a remarkable issue in MS. The results from several experimental and clinical studies indicate that vitamin D supplementation may ameliorate the inflammation during the relapse phase and attenuate disease progression. We present the experimental and clinical studies, which assessed the effects of vitamin D on the pathophysiology, prevalence and management of MS. The authors also discuss current recommendations on prescription of this vitamin to MS patients.

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